The Story of the Human Body: Evolution, Health, and Disease by Daniel E. Lieberman
designed by Matt Dorfman under the art direction of Peter Mendelsund

Here is a slightly less depressing book about, among other things, how technology has begun to coddle our bodies to such an extent that we’ve begun slowly devolving. Beyond those negatives, it does stand as a substantial account of evolution—particularly bipedalism—which is what inspired me to roll my feet in ink one fateful night and make actual human footprints for what would eventually become the chosen direction for the cover. A computer screen will do insufficient justice to the harsh neon orange that the foot is printed with to underscore the conflict between natural and unnatural changes within the body. Peter Mendelsund took a brief reprieve from being a general design ninja in order to broker this concept on the behalf of me and my foot.

New Book Covers: Dysevolution and Decay

The Story of the Human Body: Evolution, Health, and Disease by Daniel E. Lieberman

designed by Matt Dorfman under the art direction of Peter Mendelsund

Here is a slightly less depressing book about, among other things, how technology has begun to coddle our bodies to such an extent that we’ve begun slowly devolving. Beyond those negatives, it does stand as a substantial account of evolution—particularly bipedalism—which is what inspired me to roll my feet in ink one fateful night and make actual human footprints for what would eventually become the chosen direction for the cover. A computer screen will do insufficient justice to the harsh neon orange that the foot is printed with to underscore the conflict between natural and unnatural changes within the body. Peter Mendelsund took a brief reprieve from being a general design ninja in order to broker this concept on the behalf of me and my foot.

New Book Covers: Dysevolution and Decay

Interesting comment (particularly its third paragraph) by user darwinification on The New Yorker: What makes an alien intelligent?

I think I’d take this a step further and say these categories laid out are stil way too human-centric.   Why is being a social creature something that we see as so important (because we are social!).  Obv. the point though is to find intelligence that we can interact with so it makes sense…  Why not make something more unbiased, like evolutionary intelligence?  Isn’t an alligator a more intelligent  species than us (so far) because it’s managed to survive and pass on its genetic material for so much longer ?  Sure, alligators aren’t in space (yet) but they’ve evolved the survival mechanisms to last much longer than we have thus far.

I like Clarke’s description of intelligent beings as something we totally don’t even comprehend ‘waves, etc.’ 

Maybe we’ve already encountered ‘alien life’ on a number of levels and just have no idea it is life or has intelligence because of our limited capacities.  Maybe galaxies or solar systems are actually ‘intelligent.’ Humans in their limited comprehension have labeled them as galaxies, and made observations on how they work, but because we have such a small window of view based on time we don’t see them as they really are.  What if we had the ability to view galaxies or other celestial objects from a time-compressed view (a hundred million years = a second) Would galaxies then suddenly make sense as intelligent beings, swinging their celestial arms, birthing new stars and solar systems, following ‘intelligent’ patterns that we recognize better?

Fun thinking exercise.

Roosegaarde - Van Gogh Bicycle Path

Sparkling heritage in the Province of Noord-Brabant
The light stones will be used to create patterns in the path that will charge during the day and emit light during the evening. This creates an interplay of light and poetry. The design this way provides a modern interpretation to Vincent van Gogh. Cultural heritage and innovation merge in this new, public landscape. The first impressions will be presented during the symposium ‘Leading in Leisure’ on 24 October, an initiative of the Province of Noord-Brabant and part of the Dutch Design Week in Eindhoven.
The Eindhoven region will receive the first innovative bicycle path in the Netherlands. The 600 metres long bicycle path runs where Vincent van Gogh lived from 1883 to 1885 and will have a unique design comprising thousands of sparkling stones designed by artist Daan Roosegaarde. The bicycle path will be designed by Studio Roosegaarde and Heijmans and is part of a joint venture between the municipality of Eindhoven, Van Gogh Brabant, Vrijetijdshuis Brabant, Eindhoven 365 and Routebureau Brabant.
The Roosegaarde - Van Gogh bicycle path makes use of the light-emitting techniques of the Smart Highway concept, a joint development of Studio Roosegaarde and Heijmans for the highway of tomorrow. Preparations for the initial pilot of the innovative bicycle path have since begun. Plans call for the final design to be ready to be experienced in 2014, which will make this the first bicycle path of its kind in the world.

// curse-it:anorsexic

Roosegaarde - Van Gogh Bicycle Path

Sparkling heritage in the Province of Noord-Brabant

The light stones will be used to create patterns in the path that will charge during the day and emit light during the evening. This creates an interplay of light and poetry. The design this way provides a modern interpretation to Vincent van Gogh. Cultural heritage and innovation merge in this new, public landscape. The first impressions will be presented during the symposium ‘Leading in Leisure’ on 24 October, an initiative of the Province of Noord-Brabant and part of the Dutch Design Week in Eindhoven.

The Eindhoven region will receive the first innovative bicycle path in the Netherlands. The 600 metres long bicycle path runs where Vincent van Gogh lived from 1883 to 1885 and will have a unique design comprising thousands of sparkling stones designed by artist Daan Roosegaarde. The bicycle path will be designed by Studio Roosegaarde and Heijmans and is part of a joint venture between the municipality of Eindhoven, Van Gogh Brabant, Vrijetijdshuis Brabant, Eindhoven 365 and Routebureau Brabant.

The Roosegaarde - Van Gogh bicycle path makes use of the light-emitting techniques of the Smart Highway concept, a joint development of Studio Roosegaarde and Heijmans for the highway of tomorrow. Preparations for the initial pilot of the innovative bicycle path have since begun. Plans call for the final design to be ready to be experienced in 2014, which will make this the first bicycle path of its kind in the world.

// curse-it:anorsexic

reblogged via curse-it

Abrazos/Dasein,” an anatomical watercolor series by Fernanda Uribe

// christophvalse:fer1972

reblogged via christophvalse
This is amazing. Communication transduction.
letterhome by Jennifer Cantwell
// dontoverthink

This is amazing. Communication transduction.

letterhome by Jennifer Cantwell

// dontoverthink

reblogged via dontoverthink

First the players. The insect in question is the citrus pest mealybug, Planococcus citri. Like aphids and other insects that feed on the amino-acid poor phloem sap of plants, mealybugs require endosymbiotic bacteria to provide them these essential nutrients. They carry these working partners in the cytoplasm of specialized cells, the bacteriocytes. As for the bacteria, the ‘host’ is β-proteobacterium Candidatus Tremblaya princeps, called Candidatus because it cannot be grown in the lab. Its name won’t be italicized until this rule changes. It better, because T. princeps (I use italics in defiance) will never be able to grow independently as it has the smallest of all known cellular genomes: 139 kb. Living inside of it is the newly named γ-proteobacterium, Moranella endobia (also a ‘candidatus,’ but we’ll dispense with that.) The genus name honors the famed endosymbioticist Nancy Moran. The host Tremblaya cells are quite large, 10-20 μm wide; nested within are the Moranella, each 3-6 μm long and with a Gram-negative-like double membrane structure. Moranella has the audacity to possess a genome about four times larger than that of its host, a case, ostensibly, of genomic chutzpah. (» more)

1. Because it is interesting.
2. Because of the sassy science writing.

Small Things Considered: A Bug in a Bug in a Bug

reblogged via tiiigerstyle

…He and Pascal George—a younger colleague whom Kaplan described as “sympathetic and brilliant”—started by building wooden models, including ones for Valium, Halcion, and zopiclone. Colored one-inch spheres, representing atoms, were connected by thin rods, creating models the size of a shoebox. This was a more empirical, architectural approach than is typical in a lot of pharmaceutical chemistry. Kaplan and George tried to identify what these molecules had in common, structurally, that allowed them to affect the brain in the same way. Kaplan told me that their thinking wasn’t wildly creative, but it was agile: “You know, at that time it was maybe clever, because you have no computer. Now it’s routine work.”

George wrote a report describing a few possible types of new chemical compounds. Working separately, they built molecules of the first two types: about ten of one, five of the other. These were unpromising. A third series, made by George, looked better. When it was tested on animals, Kaplan said, “it was clear that it would be a great success. After the very first compound, I knew.” But in 1980, while this work was still under way, Kaplan was taken off the project. In his account, Synthélabo, eager to get rid of him, “didn’t want to give me the merit of the invention.” From then on, George ran the research. Kaplan heard only rumors about how the compounds were testing.

That fall, Synthélabo applied for a French patent on a series of seventy-seven compounds. The company knew that one of the compounds had far more pharmaceutical promise than the others, but did not need to disclose this to industry competitors. So the star molecule was also hidden from Kaplan, even though his name was at the top of the document. He showed me the patent. “I was named the first inventor, but did not have the results of the compound I proposed!” he said. He looked down a list of seventy-seven chemical formulas, and pointed to the seventy-fifth: this was Ambien. (» more)

This is an excerpt from a fascinating look at suvorexant— a Merck drug that seeks to fight insomnia without the side-effects of Ambien— from early research to drug development to FDA trials.

Ian Parker: The Search for a Blockbuster Insomnia Drug : The New Yorker

"Mathematics, rightly viewed, possesses not only truth, but supreme beauty — a beauty cold and austere, without the gorgeous trappings of painting or music." 

—Bertrand Russell

The Beauty of Mathematics by Yann Pineill & Nicolas Lefaucheux